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21.
Daniela Colomba Giovanni Duro Salvatore Corrao Christiano Argano Tiziana Di Chiara Domenico Nuzzo Federica Pizzo Gaspare Parrinello Rosario Scaglione Giuseppe Licata 《Immunity & ageing : I & A》2008,5(1):1-7
Background
Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some studies on the association between three clinically relevant eNOS gene polymorphisms (G894T, T786C and intron 4b/a) and essential hypertension are unclear. We designed a case-control study to evaluate the influence of eNOS polymorphisms on target organ damage in 127 hypertensives and 67 normotensives. Clinical evaluation, biochemical parameters, Urinary Albumin Excretion (UAE) and echocardiogram were performed to characterize target organ damage. eNOS polymorphism were recognized by PCR method.Results
The distribution of eNOS genotypes was similar in hypertensives and normotensives but 4aa was present in the 2.5% of hypertensives and completely absent in normotensives. Subjects with 4bb, G894T, and T786C genotypes showed an increased prevalence of target organ damage. Moreover prevalence of G894T and introne 4 variants was significantly higher in hypertensives than in normotensives both with cardiovascular damage. Logistic regression analysis didn't show any association between eNOS polymorphisms, Body Mass Index (BMI), hypertension, gender and cardiovascular damage. Only the age (OR 1.11; IC 95% 1.06–1.18) was predictive of cardiovascular damage in our population.Conclusion
Our results seem to indicate a lack of association with eNOS variants and cardiovascular damage onset. 相似文献22.
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 总被引:7,自引:0,他引:7
Todaro M Alea MP Di Stefano AB Cammareri P Vermeulen L Iovino F Tripodo C Russo A Gulotta G Medema JP Stassi G 《Cell Stem Cell》2007,1(4):389-402
A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor. Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer. The CD133(+) cells grow in vitro as undifferentiated tumor spheroids, and they are both necessary and sufficient to initiate tumor growth in immunodeficient mice. Xenografts resemble the original human tumor maintaining the rare subpopulation of tumorigenic CD133(+) cells. Further analysis revealed that the CD133(+) cells produce and utilize IL-4 to protect themselves from apoptosis. Consistently, treatment with IL-4Ralpha antagonist or anti-IL-4 neutralizing antibody strongly enhances the antitumor efficacy of standard chemotherapeutic drugs through selective sensitization of CD133(+) cells. Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4. 相似文献
23.
Bonanomi Giuliano Sarker Tushar C. Zotti Maurizio Cesarano Gaspare Allevato Emilia Mazzoleni Stefano 《Plant and Soil》2019,441(1-2):129-146
Plant and Soil - The processes of nitrogen (N) mineralization from organic amendments (OA) is important to provide mineral forms (NH4+ and NO3?) of N for plants. Assessment of N... 相似文献
24.
Gaspare La Rocca Bin Shi Laura Sepp‐Lorenzino Renato Baserga 《Journal of cellular physiology》2011,226(3):602-607
Micro‐RNA‐145 (miR145), a tumor suppressor miR, dramatically inhibits growth of cancer cells in culture and plays a significant role in human stem cells differentiation. We have isolated a human genomic sequence of 864 bp comprising the pre‐miR and its flanking sequences. The cloned miR145 genomic sequence expresses a mature miR145 in transfected cells. We show here that flanking sequences on either side of the pre‐miR sequence can modulate its expression levels. Surprisingly, a highly conserved sequence 3′ to the pre‐miR plays a crucial role in miR145 expression. J. Cell. Physiol. 226: 602–607, 2011. © 2010 Wiley‐Liss, Inc. 相似文献
25.
Salvatore Petta Oreste Marrone Daniele Torres Maria Buttacavoli Calogero Cammà Vito Di Marco Anna Licata Anna Lo Bue Gaspare Parrinello Antonio Pinto Adriana Salvaggio Antonino Tuttolomondo Antonio Craxì Maria Rosaria Bonsignore 《PloS one》2015,10(12)
Background/Aims
We assessed whether obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with severity of liver fibrosis and carotid atherosclerosis in patients with biopsy-proven NAFLD and low prevalence of morbid obesity. Secondary aim was to explore the association of OSA and hypoxemia with NASH and severity of liver pathological changes.Methods
Consecutive patients (n = 126) with chronically elevated ALT and NAFLD underwent STOP-BANG questionnaire to estimate OSA risk and ultrasonographic carotid assessment. In patients accepting to perform cardiorespiratory polygraphy (PG, n = 50), OSA was defined as an apnea/hypopnea index ≥5. A carotid atherosclerotic plaque was defined as a focal thickening >1.3 mm.Results
Prevalence of high OSA risk was similar in patients refusing or accepting PG (76% vs 68%, p = 0.17). Among those accepting PG, overall OSA prevalence was significantly higher in patients with F2-F4 fibrosis compared to those without (72% vs 44%; p = 0.04). Significant fibrosis was independently associated with mean nocturnal oxygen saturation (SaO2)<95% (OR 3.21, 95%C.I. 1.02–7.34; p = 0.04). Prevalence of OSA tended to be higher in patients with, than in those without, carotid plaques (64% vs 40%; p = 0.08). Carotid plaques were independently associated with %time at SaO2<90% >1 (OR 6.30, 95%C.I. 1.02–12.3; p = 0.01).Conclusions
In NAFLD patients with chronically elevated ALT at low prevalence of morbid obesity, OSA was highly prevalent and indexes of SaO2 resulted independently associated with severity of liver fibrosis and carotid atherosclerosis. These data suggest to consider sleep disordered breathing as a potential additional therapeutic target in severe NAFLD patients. 相似文献26.
Vanda Viola Annalisa Tosoni Ambra Brizi Ilaria Salvato Arie W. Kruglanski Gaspare Galati Lucia Mannetti 《PloS one》2015,10(12)
The aim of this study was to assess the extent to which Need for Cognitive Closure (NCC), an individual-level epistemic motivation, can explain inter-individual variability in the cognitive effort invested on a perceptual decision making task (the random motion task). High levels of NCC are manifested in a preference for clarity, order and structure and a desire for firm and stable knowledge. The study evaluated how NCC moderates the impact of two variables known to increase the amount of cognitive effort invested on a task, namely task ambiguity (i.e., the difficulty of the perceptual discrimination) and outcome relevance (i.e., the monetary gain associated with a correct discrimination). Based on previous work and current design, we assumed that reaction times (RTs) on our motion discrimination task represent a valid index of effort investment. Task ambiguity was associated with increased cognitive effort in participants with low or medium NCC but, interestingly, it did not affect the RTs of participants with high NCC. A different pattern of association was observed for outcome relevance; high outcome relevance increased cognitive effort in participants with moderate or high NCC, but did not affect the performance of low NCC participants. In summary, the performance of individuals with low NCC was affected by task difficulty but not by outcome relevance, whereas individuals with high NCC were influenced by outcome relevance but not by task difficulty; only participants with medium NCC were affected by both task difficulty and outcome relevance. These results suggest that perceptual decision making is influenced by the interaction between context and NCC. 相似文献
27.
Gaspare La Rocca Margherita Badin Bin Shi Shi‐Qiong Xu Tiziana DeAngelis Laura Sepp‐Lorenzinoi Renato Baserga 《Journal of cellular physiology》2009,220(2):485-491
MicroRNA 145 (miR145) has been proposed as a tumor suppressor. It was previously shown that miR145 targets the 3′ UTR of the insulin receptor substrate‐1 (IRS‐1) and dramatically inhibits the growth of colon cancer cells. miR145 also targets the type 1 insulin‐like growth factor receptor (IGF‐IR). We show here that an IRS‐1 lacking its 3′ UTR is no longer down‐regulated by miR145 and rescues colon cancer cells from miR145‐induced inhibition of growth. An IGF‐IR resistant to miR145 (again by elimination of its 3′ UTR) is not down‐regulated by miR145 but fails to rescue colon cancer cells from growth inhibition. These and other results, taken together, indicate that down‐regulation of IRS‐1 plays a significant role in the tumor suppressor activity of miR145. J. Cell. Physiol. 220: 485–491, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
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29.
The synthesis of the repeating unit of the major O-antigen component from Pseudomonas syringae pv. ribicola NVPPB 1010 is reported. The strategy used was based on the successive coupling of a trisaccharide rhamnosyl trichloroacetimidate with a rhamnosyl acceptor with a free hydroxyl group on C-2. The pentasaccharide was then obtained by coupling with a N-Troc-tri-O-acetyl-glucosamine trichloroacetimidate. The synthesis allowed the oligomerisation of the repeating unit. 相似文献
30.
Matteo Adinolfi Gaspare Barone Rosa Lanzetta Guglielmo Laonigro Lorenzo Mangoni Michelangelo Parrilli 《Phytochemistry》1985,24(3):624-626
Three novel 3-benzyl-4-chromanones have been isolated from the bulbs of Muscari comosum. 相似文献